BMS-599626 (Hydrochloride)
Product Sizes
10 mg
£ POA
HY-12010-10MG
50 mg
£ POA
HY-12010-50MG
5 mg
£ POA
HY-12010-5MG
100 mg
£ POA
HY-12010-100MG
10mM/1mL
£ POA
HY-12010-10MM
25 mg
£ POA
HY-12010-25MG
About this Product
- SKU:
- HY-12010
- Additional Names:
- AC480 (Hydrochloride)
- CAS Number:
- 873837-23-1
- Extra Details:
- BMS-599626 Hydrochloride (AC480 Hydrochloride) is a selective and orally bioavailable HER1 and HER2 inhibitor; with IC50s of 20 and 30 nM; respectively. BMS-599626 Hydrochloride displays ~8-fold less potent to HER4 (IC50=190 nM); >100-fold to VEGFR2; c-Kit; Lck; MEK. BMS-599626 Hydrochloride inhibits tumor cell proliferation; and has potential to increase tumor response to radiotherapy[1][2].
- Molecular Weight:
- 567.01
- Purity:
- 98.90
- References:
- [1]Wong TW, et al. Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6186-93.|[2]Torres MA, et al. AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo. Invest New Drugs. 2011 Aug;29(4):554-61.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; sealed storage; away from moisture)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
