(rel)-AR234960
Product Sizes
5 mg
£ POA
HY-120006A-5MG
50 mg
£ POA
HY-120006A-50MG
10 mg
£ POA
HY-120006A-10MG
100 mg
£ POA
HY-120006A-100MG
10mM/1mL
£ POA
HY-120006A-10MM
About this Product
- SKU:
- HY-120006A
- CAS Number:
- 1408311-94-3
- Extra Details:
- (rel)-AR234960 is a selective and competitive agonist of the G protein-coupled receptor MAS. (rel)-AR234960 binds to the MAS receptor to activate the downstream ERK1/2 signaling pathway; inducing the expression of connective tissue growth factor (CTGF) and its downstream collagen subtype genes (such as COL1A1; COL3A1). (rel)-AR234960 promotes collagen synthesis in cardiac fibroblasts through the MAS-ERK1/2-CTGF pathway and aggravates extracellular matrix remodeling. (rel)-AR234960's in vitro effect can be blocked by the MAS inverse agonist AR244555 and MEK1 inhibitor. (rel)-AR234960 regulates the expression of cardiac fibrosis-related genes and can be used in the study of heart failure[1][2].
- Molecular Weight:
- 555.62
- Purity:
- 98.95
- References:
- [1]Chen Z, et al. Suppression of Skp2 contributes to sepsis-induced acute lung injury by enhancing ferroptosis through the ubiquitination of SLC3A2. Cell Mol Life Sci. 2024 Jul 30;81(1):325.|[2]Chatterjee A, et al. Connective tissue growth factor dependent collagen gene expression induced by MAS agonist AR234960 in human cardiac fibroblasts. PLoS One. 2017 Dec 29;12(12):e0190217.
- Research Area:
- Cardiovascular Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- MAPK/ERK Pathway;Stem Cell/Wnt
