Fialuridine
Product Sizes
25 mg
£ POA
HY-118122-25MG
50 mg
£ POA
HY-118122-50MG
100 mg
£ POA
HY-118122-100MG
5 mg
£ POA
HY-118122-5MG
10 mg
£ POA
HY-118122-10MG
10mM/1mL
£ POA
HY-118122-10MM
About this Product
- SKU:
- HY-118122
- Additional Names:
- FIAU; DRG-0098; NSC 678514
- CAS Number:
- 69123-98-4
- Extra Details:
- Fialuridine (FIAU); a nucleoside analog; is a HSV-1 and HSV-2 inhibitor with Kis of 0.14 μM and 0.95 μM; respectively. Fialuridine shows anti-orthopoxvirus and anti-hepatitis B virus (HBV) activities. Fialuridine inhibits duck HBV DNA replication with IC50 values of 0.075 μM and 156 μM in human hepatoma cells and in chicken liver cells; respectively[1][2][3].
- Molecular Weight:
- 372.09
- Purity:
- 99.91
- References:
- [1]Mansuri MM, et al. 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil. A highly selective antiherpes simplex agent. J Med Chem. 1987 May;30(5):867-71. |[2]Mark N Prichard, et al. Orthopoxvirus targets for the development of antiviral therapies. Curr Drug Targets Infect Disord. 2005 Mar;5(1):17-28. |[3]Staschke KA, et al. The in vitro anti-hepatitis B virus activity of FIAU [1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl-5-iodo)uracil] is selective, reversible, and determined, at least in part, by the host cell. Antiviral Res. 1994 Jan;23(1):45-61.|[4]Richardson FC, et al. Fialuridine accumulates in DNA of dogs, monkeys, and rats following long-term oral administration. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12003-7.
- Research Area:
- Infection
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Anti-infection;Cell Cycle/DNA Damage
