(S)-JQ-35
Product Sizes
50 mg
£ POA
HY-117286-50MG
100 mg
£ POA
HY-117286-100MG
10 mg
£ POA
HY-117286-10MG
5 mg
£ POA
HY-117286-5MG
25 mg
£ POA
HY-117286-25MG
10mM/1mL
£ POA
HY-117286-10MM
About this Product
- SKU:
- HY-117286
- Additional Names:
- TEN-010
- Application:
- Antibody Microarray
- CAS Number:
- 1349719-98-7
- Extra Details:
- (S)-JQ-35 (TEN-010) is a selective bromodomain and extra-terminal domain (BET) protein family inhibitor targeting BRD4; BRD3; BRD2 and BRDT. (S)-JQ-35 is orally active and can penetrate the blood-brain barrier. (S)-JQ-35 competitively binds to the bromodomain of BRD4; preventing it from binding to the Myc gene promoter; thereby inhibiting cancer cell proliferation and inducing cell apoptosis. (S)-JQ-35 can be used for targeted therapy research of malignant tumors such as NUT midline carcinoma and refractory solid tumors[1][2].
- Molecular Weight:
- 540.12
- Purity:
- 99.46
- References:
- [1]Samples S, et al. Intrapericardial NUT Midline Carcinoma: Unusual Presentation of a Rare Tumor and Literature Review with Management Considerations. Pediatr Cardiol. 2016 Jan;37(1):208-11.|[2]Sharifi Z, et al. Pharmacokinetics of ZR2002, a combi-molecule with EGFR and DNA-damaging properties and its efficacy in an orthotopic glioblastoma mouse model[J]. Annals of Oncology, 2018, 29: iii12.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Epigenetics
