(E;E)-GLL398
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HY-114770-1EACH
About this Product
- SKU:
- HY-114770
- Application:
- Antibody Microarray
- CAS Number:
- 2077980-83-5
- Extra Details:
- (E;E)-GLL398 is a selective estrogen receptor degrader with potent binding activity to ERα (IC50 = 1.14 nM). (E;E)-GLL398 can effectively degrade ERα in MCF-7 breast cancer cells (IC50 = 0.21 μM). The introduced boronic acid group of (E;E)-GLL398 gives it superior oral bioavailability; with an AUC of 36.9 μg·h/mL in rats; which is significantly higher than that of GW7604[1].
- Molecular Weight:
- 398.26
- References:
- [1]Rational Design of a Boron-Modified Triphenylethylene (GLL398) as an Oral Selective Estrogen Receptor Downregulator
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
