1-Methyladenosine-d3
Product Sizes
1 mg
£ POA
HY-113081S-1MG
10 mg
£ POA
HY-113081S-10MG
5 mg
£ POA
HY-113081S-5MG
About this Product
- SKU:
- HY-113081S
- Extra Details:
- 1-Methyl Adenosine-d3 is the deuterium labeled 1-Methyladenosine. 1-Methyladenosine is an RNA modification that can serve as a tumor marker; with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation; upregulation of PPARδ expression regulates cholesterol metabolism and activates Hedgehog signaling pathway; driving liver tumorigenesis[1][2][3][4].
- Molecular Weight:
- 284.29
- Purity:
- 96.12
- References:
- [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Hauenschild R, et al. The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependent. Nucleic Acids Res. 2015 Nov 16;43(20):9950-64.|[3]Banys K, et al. Effect of Genistein Supplementation on the Progression of Neoplasms and the Level of the Modified Nucleosides in Rats With Mammary Cancer. In Vivo. 2021 Jul-Aug;35(4):2059-2072. |[4]Wang Y, et al. N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism[J]. Nature communications, 2021, 12(1): 6314.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
