1-Methyladenosine-d3 (hydrochloride)
Product Sizes
1 mg
£ POA
HY-113081AS-1MG
5 mg
£ POA
HY-113081AS-5MG
About this Product
- SKU:
- HY-113081AS
- Application:
- Antibody Microarray
- Extra Details:
- 1-Methyladenosine-d3 hydrochloride is the hydrochloride salt form of deuterium labeled 1-Methyladenosine (HY-113081). 1-Methyladenosine is an RNA modification that can serve as a tumor marker; with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation; upregulation of PPARδ expression regulates cholesterol metabolism and activates Hedgehog signaling pathway; driving liver tumorigenesis[1][2][3][4].
- Molecular Weight:
- 320.75
- Purity:
- 98.05
- References:
- [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Hauenschild R, et al. The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependent. Nucleic Acids Res. 2015 Nov 16;43(20):9950-64.|[3]Banys K, et al. Effect of Genistein Supplementation on the Progression of Neoplasms and the Level of the Modified Nucleosides in Rats With Mammary Cancer. In Vivo. 2021 Jul-Aug;35(4):2059-2072.|[4]Wang Y, et al. N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism[J]. Nature communications, 2021, 12(1): 6314.
- Research Area:
- Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C (Powder; sealed storage; away from moisture and light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Others;Stem Cell/Wnt;Vitamin D Related/Nuclear Receptor
