Inotersen
Product Sizes
1 mg
£ POA
HY-112974-1MG
5 mg
£ POA
HY-112974-5MG
10 mg
£ POA
HY-112974-10MG
20 mg
£ POA
HY-112974-20MG
About this Product
- SKU:
- HY-112974
- Additional Names:
- GSK-2998728; ISIS-420915
- CAS Number:
- 1492984-65-2
- Extra Details:
- Inotersen (GSK-2998728; ISIS-420915) is a 2'-O-methoxyethyl-modified antisense oligonucleotide and transthyretin (TTR) inhibitor with low genotoxicity. Inotersen triggers RNase H1-mediated degradation by binding to TTR mRNA; thereby effectively reducing the production of both mutant and wild-type transthyretin in the liver. Inotersen significantly reduces amyloid fiber deposition; yet specific toxicities such as inflammation or tumors are observed at high doses in some animal models. Inotersen is used in studies of hereditary transthyretin amyloidosis and the associated polyneuropathy and cardiomyopathy[1][2][3][4].
- Molecular Weight:
- 7183.08
- Purity:
- 96.44
- References:
- [1]Benson MD, Waddington-Cruz M, Berk JL, et al. Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis. N Engl J Med. 2018;379(1):22-31.|[2]Mathew V, Wang AK. Inotersen: new promise for the treatment of hereditary transthyretin amyloidosis. Drug Des Devel Ther. 2019;13:1515-1525. Published 2019 May 6.
- Research Area:
- Cardiovascular Disease;Neurological Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C (Powder; stored under nitrogen; away from moisture)
- Type:
- Molecular Biology Reagents: Nucleic Acids
