1;2;3;6-Tetragalloylglucose
Product Sizes
1 mg
£ POA
HY-111832-1MG
10 mg
£ POA
HY-111832-10MG
5 mg
£ POA
HY-111832-5MG
10mM/1mL
£ POA
HY-111832-10MM
About this Product
- SKU:
- HY-111832
- Additional Names:
- TeGG
- Application:
- Immunoprecipitation
- CAS Number:
- 79886-50-3
- Extra Details:
- 1;2;3;6-Tetragalloylglucose (TEgG) is a competitive inhibitor of UDP-glucuronyltransferase UGT1A1; targeting the competitive substrate binding site of UGT1A1. 1;2;3;6-Tetragalloylglucose inhibits UGT1A1-mediated β-estradiol 3-glucuronidation and SN-38 glucuronidation with IC50 of 6.01 μM and 4.31 μM; respectively; and binds to UGT1A1 with Ki of 3.55 μM. 1;2;3;6-Tetragalloylglucose also induces tumor cell apoptosis; inhibit cell proliferation; activates caspase-3 and induces DNA fragmentation in HL-60 cells. 1;2;3;6-Tetragalloylglucose also inhibits HIV integrase and reverse transcriptase; and inhibits HCV protease[1][2][3].
- Molecular Weight:
- 788.57
- Purity:
- 99.08
- References:
- [1]Park JB, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018 Oct;120:651-661.|[2]Min Byung-Sun, et al. Apoptosis-inducing activity of galloylglucoses from Juglans mandshurica in human promyeloid leukemic HL-60 cells. Natural Product Sciences 10.1 (2004): 48-53.|[3]Zhang J, et al. Anti-cancer, anti-diabetic and other pharmacologic and biological activities of penta-galloyl-glucose. Pharm Res. 2009 Sep;26(9):2066-80.
- Research Area:
- Infection; Metabolic Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; protect from light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Metabolic Enzyme/Protease
