SPP-86
Product Sizes
100 mg
£ POA
HY-110193-100MG
25 mg
£ POA
HY-110193-25MG
10 mg
£ POA
HY-110193-10MG
50 mg
£ POA
HY-110193-50MG
5 mg
£ POA
HY-110193-5MG
10mM/1mL
£ POA
HY-110193-10MM
About this Product
- SKU:
- HY-110193
- CAS Number:
- 1357349-91-7
- Extra Details:
- SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase; with an IC50 of 8 nM. SPP-86 inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling; also inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells[1]. SPP-86 is a click chemistry reagent; it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Molecular Weight:
- 277.32
- Purity:
- 99.87
- References:
- [1]Alao JP, et al. Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86. BMC Cancer. 2014 Nov 20;14:853.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Protein Tyrosine Kinase/RTK
