SP-100030
Product Sizes
5 mg
£ POA
HY-110177-5MG
50 mg
£ POA
HY-110177-50MG
25 mg
£ POA
HY-110177-25MG
100 mg
£ POA
HY-110177-100MG
10 mg
£ POA
HY-110177-10MG
10mM/1mL
£ POA
HY-110177-10MM
About this Product
- SKU:
- HY-110177
- CAS Number:
- 154563-54-9
- Extra Details:
- SP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC50s=50 and 50 nM; respectively). SP-100030 inhibits IL-2; IL-8; and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA)[1][2].
- Molecular Weight:
- 437.65
- Purity:
- 99.57
- References:
- [1]Sullivan RW, et al. 2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3',5'- bis(trifluoromethyl)phenyl)-carboxamide: a potent inhibitor of NF-kappa B- and AP-1-mediated gene expression identified using solution-phase combinatorial chemistry. J Med Chem. 1998;41(4):413-419.|[2]Gerlag DM, et al. The effect of a T cell-specific NF-kappa B inhibitor on in vitro cytokine production and collagen-induced arthritis. J Immunol. 2000;165(3):1652-1658.
- Research Area:
- Inflammation/Immunology
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- NF-κB
