Marizomib
Product Sizes
1 mg
£ POA
HY-10985-1MG
5 mg
£ POA
HY-10985-5MG
100 μg
£ POA
HY-10985-100UG
500 μg
£ POA
HY-10985-500UG
10mM/1mL
£ POA
HY-10985-10MM
About this Product
- SKU:
- HY-10985
- Additional Names:
- Salinosporamide A; NPI-0052
- CAS Number:
- 437742-34-2
- Extra Details:
- Marizomib (Salinosporamide A) is a second-generation; irreversible; brain-penetrant; pan-proteasome inhibitor. Marizomib inhibits the CT-L (β5); CT-T-laspase-like (C-L; β1) and trypsin-like (T-L; β2) activities of the 20S proteasome (IC50=3.5; 28; and 430 nM; respectively)[1][2][3].
- Molecular Weight:
- 313.78
- Purity:
- 99.13
- References:
- [1]Di K, et al. Marizomib activity as a single agent in malignant gliomas: ability to cross the blood-brainbarrier. Neuro Oncol. 2016 Jun;18(6):840-8.|[2]Kale AJ, et al. Molecular mechanisms of acquired proteasome inhibitor resistance. J Med Chem. 2012 Dec 13;55(23):10317-27.|[3]Singh AV, et al. Pharmacodynamic and efficacy studies of the novel proteasome inhibitor NPI-0052 (marizomib) in a human plasmacytoma xenograft murine model. Br J Haematol. 2010 May;149(4):550-9.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Metabolic Enzyme/Protease
