(Rac)-Upacicalcet
Product Sizes
10 mg
£ POA
HY-109106B-10MG
5 mg
£ POA
HY-109106B-5MG
About this Product
- SKU:
- HY-109106B
- Additional Names:
- (Rac)-SK-1403 (free acid); (Rac)-AJT240 (free acid); (Rac)-PLS240 (free acid)
- Application:
- Electron Microscopy
- CAS Number:
- 2649575-19-7
- Extra Details:
- (Rac)-Upacicalcet is the racemate of Upacicalcet (HY-109106). Upacicalcet is a non-peptide calcimimetic that acts as a CaSR agonist (EC50 = 10.8 nM). Upacicalcet reduces serum intact parathyroid hormone (iPTH) and serum Ca2+ levels; reducing hypocalcemia and gastrointestinal complications. Upacicalcet improves vascular calcification and bone disorders in the Adenine (HY-B0152)-induced secondary hyperparathyroidism (SHPT) rat model. Upacicalcet inhibits cortical pore formation and reduces bone fibrosis in rats with chronic kidney disease (CKD). Upacicalcet is useful for studying SHPT[1][2].
- Molecular Weight:
- 351.76
- Purity:
- 95.0
- References:
- [1]Hoy SM. Upacicalcet: First Approval. Drugs. 2021;81(13):1593-1596.
- Research Area:
- Endocrinology
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- GPCR/G Protein
