Upacicalcet
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HY-109106-1EACH
About this Product
- SKU:
- HY-109106
- Additional Names:
- SK-1403 (free acid); AJT240 (free acid); PLS240 (free acid)
- Application:
- Electron Microscopy
- CAS Number:
- 1333218-50-0
- Extra Details:
- Upacicalcet is a non-peptide calcimimetic that acts as a CaSR agonist (EC50 = 10.8 nM). Upacicalcet reduces serum intact parathyroid hormone (iPTH) and serum Ca2+ levels; reducing hypocalcemia and gastrointestinal complications. Upacicalcet improves vascular calcification and bone disorders in the Adenine (HY-B0152)-induced secondary hyperparathyroidism (SHPT) rat model. Upacicalcet inhibits cortical pore formation and reduces bone fibrosis in rats with chronic kidney disease (CKD). Upacicalcet is useful for studying SHPT[1][2].
- Molecular Weight:
- 351.76
- References:
- [1]Hoy SM. Upacicalcet: First Approval. Drugs. 2021;81(13):1593-1596.
- Research Area:
- Endocrinology
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
