Otaplimastat
Product Sizes
10 mg
£ POA
HY-109097-10MG
5 mg
£ POA
HY-109097-5MG
100 mg
£ POA
HY-109097-100MG
50 mg
£ POA
HY-109097-50MG
25 mg
£ POA
HY-109097-25MG
10mM/1mL
£ POA
HY-109097-10MM
About this Product
- SKU:
- HY-109097
- Additional Names:
- SP-8203
- CAS Number:
- 1176758-04-5
- Extra Details:
- Otaplimastat (SP-8203); a matrix metalloproteinase (MMP) inhibitor; blocks N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity in a competitive manner. Otaplimastat also exhibits anti-oxidant activity. Otaplimastat can be used for the research of brain ischemic injury[1][2][3].
- Molecular Weight:
- 534.61
- Purity:
- 98.11
- References:
- [1]Noh SJ, et, al. SP-8203 shows neuroprotective effects and improves cognitive impairment in ischemic brain injury through NMDA receptor. Pharmacol Biochem Behav. 2011 Nov;100(1):73-80.|[2]Noh SJ, et, al. SP-8203 reduces oxidative stress via SOD activity and behavioral deficit in cerebral ischemia. Pharmacol Biochem Behav. 2011 Mar;98(1):150-4.|[3]Kim JS, et, al. Safety and Efficacy of Otaplimastat in Patients with Acute Ischemic Stroke Requiring tPA (SAFE-TPA): A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Study. Ann Neurol. 2020 Feb;87(2):233-245.
- Research Area:
- Cancer;Inflammation/Immunology;Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
