(1S;2R)-Alicapistat
Product Sizes
5 mg
£ POA
HY-109001A-5MG
50 mg
£ POA
HY-109001A-50MG
1 mg
£ POA
HY-109001A-1MG
10 mg
£ POA
HY-109001A-10MG
25 mg
£ POA
HY-109001A-25MG
About this Product
- SKU:
- HY-109001A
- Additional Names:
- (1S;2R)-ABT-957
- CAS Number:
- 2221010-57-5
- Extra Details:
- (1S;2R)-Alicapistat ((1S;2R)-ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimer's disease (AD)[1]. (1S;2R)-Alicapistat mitigates the metabolic liability of carbonyl reduction and inhibits calpain 1 with an IC50 value of 395 nM[2].
- Molecular Weight:
- 433.50
- Purity:
- 98.0
- References:
- [1]Lon HK, et al. Pharmacokinetics, Safety, Tolerability, and Pharmacodynamics of Alicapistat, a Selective Inhibitor of Human Calpains 1 and 2 for the Treatment of Alzheimer Disease: An Overview of Phase 1 Studies. Clin Pharmacol Drug Dev. 2019 Apr. 8(3):290-303.|[2]Jantos K, et al. Discovery of ABT-957: 1-Benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability. Bioorg Med Chem Lett. 2019 Aug 1. 29(15):1968-1973. |[3]Jastaniah A, Gaisina IN, Knopp RC, Thatcher GRJ. Synthesis of α-Ketoamide-Based Stereoselective Calpain-1 Inhibitors as Neuroprotective Agents. ChemMedChem. 2020 Dec 3. 15(23):2280-2285.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Metabolic Enzyme/Protease
