(S)-Ro 32-0432 (free base)
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HY-108601-1EACH
About this Product
- SKU:
- HY-108601
- CAS Number:
- 151342-35-7
- Extra Details:
- (S)-Ro 32-0432 free base is a potent; selective; ATP-competitive and orally active PKC inhibitor. The IC50 values of (S)-Ro 32-0432 free base for PKCα; PKCβI; PKCβII; PKCγ and PKCε are 9.3 nM; 28 nM; 30 nM; 36.5 nM and 108.3 nM; respectively. (S)-Ro 32-0432 free base is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor. (S)-Ro 32-0432 free base prevents T-cell activation and has the potential for chronic inflammatory and autoimmune diseases research[1][2].
- Molecular Weight:
- 452.55
- References:
- [1]A M Birchall, et al. Ro 32-0432, a Selective and Orally Active Inhibitor of Protein Kinase C Prevents T-cell Activation. J Pharmacol Exp Ther. 1994 Feb;268(2):922-9.|[2]Thakur Gurjeet Singh, et al. Ro 32-0432 Attenuates Mecamylamine-Precipitated Nicotine Withdrawal Syndrome in Mice. Naunyn Schmiedebergs Arch Pharmacol. 2013 Mar;386(3):197-204.
- Research Area:
- Inflammation/Immunology
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
