MK-2206
Product Sizes
5 mg
£ POA
HY-108232-5MG
10 mg
£ POA
HY-108232-10MG
10mM/1mL
£ POA
HY-108232-10MM
About this Product
- SKU:
- HY-108232
- CAS Number:
- 1032349-77-1
- Extra Details:
- MK-2206 is an orally active; highly potent and selective allosteric Akt inhibitor; with IC50s of 8; 12; and 65 nM for Akt1; Akt2; and Akt3; respectively. Many breast cancer cell lines; and PIK3CA-mutant and cell lines with PTEN loss are sensitive to MK-2206. MK-2206 has anticancer activities[1][2].
- Molecular Weight:
- 443.93
- Purity:
- 99.72
- References:
- [1]Xing Y, et al. Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation. Breast Cancer Res. 2019 Jul 5;21(1):78.|[2]Zhao YY, et al. Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo. Drug Des Devel Ther. 2014 Oct 10;8:1827-37.|[3]Agarwal E, et al. Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer. BMC Cancer. 2014 Mar 1;14:145.|[4]Li Yan, et al. Abstract #DDT01-1: MK-2206: A potent oral allosteric AKT inhibitor. 2009.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; sealed storage; away from moisture)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Apoptosis;Autophagy;PI3K/Akt/mTOR;Stem Cell/Wnt
