1-Oleoyl lysophosphatidic acid (sodium) (GMP)
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HY-107614G-1EACH
About this Product
- SKU:
- HY-107614G
- Additional Names:
- 1-Oleoyl-sn-glycero-3-phosphate (sodium) (GMP); 1-Oleoyl-LPA (sodium) (GMP)
- CAS Number:
- 325465-93-8
- Extra Details:
- 1-Oleoyl lysophosphatidic acid sodium (GMP) is the GMP-grade form of 1-Oleoyl lysophosphatidic acid sodium (HY-107614). GMP-grade small molecules serve as auxiliary reagents in cell therapy. 1-Oleoyl lysophosphatidic acid sodium is a bioactive lipid signaling molecule. 1-Oleoyl lysophosphatidic acid sodium inhibits lysoPLD-catalyzed hydrolysis of lysophosphatidylcholine and FS-3. 1-Oleoyl lysophosphatidic acid sodium activates LPA1 and LPA2; thereby triggering calcium mobilization; NFATc1 translocation; Rho/ROCK activation; Smad2/3 phosphorylation and c-Fos expression. 1-Oleoyl lysophosphatidic acid sodium induces anxiety-like; depression-like and hypoactivity phenotypes; regulates osteoclast cytoskeleton and viability; reduces osteoclast bone resorptive activity; and drives mesenchymal stem cell differentiation into myofibroblast-like cells. 1-Oleoyl lysophosphatidic acid sodium stimulates the secretion of transforming growth factor-β1 and stromal cell-derived factor-1. 1-Oleoyl lysophosphatidic acid sodium is applicable to research related to anxiety; depression and ovarian cancer[1][2][3][4].
- Molecular Weight:
- 458.50
- References:
- [1]Eun Su Jeon, et al. Cancer-derived lysophosphatidic acid stimulates differentiation of human mesenchymal stem cells to myofibroblast-like cells. Stem Cells. 2008 Mar;26(3):789-97.|[2]Hui-Lin Cui, et al. Promotive action of lysophosphatidic acid on proliferation of rat embryonic neural stem cells and their differentiation to cholinergic neurons in vitro. Sheng Li Xue Bao. 2006 Dec 25;58(6):547-55.
- Research Area:
- Cancer;Neurological Disease
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
