PD-166793
Product Sizes
50 mg
£ POA
HY-107428-50MG
5 mg
£ POA
HY-107428-5MG
25 mg
£ POA
HY-107428-25MG
100 mg
£ POA
HY-107428-100MG
10 mg
£ POA
HY-107428-10MG
10mM/1mL
£ POA
HY-107428-10MM
About this Product
- SKU:
- HY-107428
- CAS Number:
- 199850-67-4
- Extra Details:
- PD-166793 is a potent; selective; orally active and wide-broad spectrum inhibitor of MMP; exhibiting nanomolar potency against MMP-2; MMP-3 and MMP-13 (IC50=4; 7; and 8 nM; respectively) and micromolar potency vs MMP-1; -7 and -9 (IC50=6.0; 7.2; and 7.9 μM; respectively). PD-166793 can attenuate left ventricular remodeling and dysfunction in a rat model of progressive heart failure[1][2][3].
- Molecular Weight:
- 412.30
- Purity:
- 99.21
- References:
- [1]O'Brien PM, et, al. Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available biphenylsulfonamide matrix metalloproteinase inhibitors. J Med Chem. 2000 Jan 27;43(2):156-66.|[2]Kaludercic N, et, al. Inhibiting metalloproteases with PD 166793 in heart failure: impact on cardiac remodeling and beyond. Cardiovasc Ther. Spring 2008;26(1):24-37.|[3]Chancey AL, et, al. Effects of matrix metalloproteinase inhibition on ventricular remodeling due to volume overload. Circulation. 2002 Apr 23;105(16):1983-8.
- Research Area:
- Cardiovascular Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Metabolic Enzyme/Protease
