(+)-EMD 57033
Product Sizes
1 mg
£ POA
HY-106844A-1MG
5 mg
£ POA
HY-106844A-5MG
10 mg
£ POA
HY-106844A-10MG
About this Product
- SKU:
- HY-106844A
- CAS Number:
- 147527-31-9
- Extra Details:
- (+)-EMD 57033 is a cardiac troponin C (cTnC) activator; is a dominant Ca2+ sensitizer. (+)-EMD 57033 binds the cardiac/slow skeletal troponin C isoform and exerts myocardial contractile promotion function[1].
- Molecular Weight:
- 425.50
- Purity:
- 99.72
- References:
- [1]Wang X, et al. Structure of the C-domain of human cardiac troponin C in complex with the Ca2+ sensitizing drug EMD 57033. J Biol Chem. 2001 Jul 6;276(27):25456-66. |[2]Ochala J, et al. EMD 57033 partially reverses ventilator-induced diaphragm muscle fibre calcium desensitisation. Pflugers Arch. 2010 Feb;459(3):475-83. |[3]Hgashiyama A, et al. Effects of EMD 57033 on contraction and relaxation in isolated rabbit hearts. Circulation. 1995 Nov 15;92(10):3094-104. |[4]Senzaki H, et al. Improved mechanoenergetics and cardiac rest and reserve function of in vivo failing heart by calcium sensitizer EMD-57033. Circulation. 2000 Mar 7;101(9):1040-8.
- Research Area:
- Cardiovascular Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Others
