Crisdesalazine
Product Sizes
25 mg
£ POA
HY-105005-25MG
1 mg
£ POA
HY-105005-1MG
5 mg
£ POA
HY-105005-5MG
50 mg
£ POA
HY-105005-50MG
10 mg
£ POA
HY-105005-10MG
About this Product
- SKU:
- HY-105005
- Additional Names:
- AAD-2004
- CAS Number:
- 927685-43-6
- Extra Details:
- Crisdesalazine (AAD-2004) is a microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. Crisdesalazine acts as a potent free radical scavenger that directly neutralizes reactive oxygen species (ROS) including hydrogen peroxide; exerting neuroprotective effects against apoptosis and axonal damage. Crisdesalazine inhibits PGE2 production; mediates inflammatory responses; and promotes the conversion of macrophages from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype. Crisdesalazine is applicable to neuroprotection research in multiple sclerosis and spinal cord injury[1][2].
- Molecular Weight:
- 325.28
- Purity:
- 98.92
- References:
- [1]Shin JH, et al. Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. J Neurochem. 2012 Sep;122(5):952-61.
- Research Area:
- Inflammation/Immunology;Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- GPCR/G Protein
