Ki20227
Product Sizes
50 mg
£ POA
HY-10408-50MG
5 mg
£ POA
HY-10408-5MG
100 mg
£ POA
HY-10408-100MG
25 mg
£ POA
HY-10408-25MG
2 mg
£ POA
HY-10408-2MG
10 mg
£ POA
HY-10408-10MG
10mM/1mL
£ POA
HY-10408-10MM
About this Product
- SKU:
- HY-10408
- CAS Number:
- 623142-96-1
- Extra Details:
- Ki20227 is an orally active and highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC50s of 2 nM; 12 nM; 451 and 217 nM for CSF1R; VEGFR2 (vascular endothelial growth factor receptor-2); c-Kit (stem cell factor receptor) and PDGFRβ (platelet-derived growth factor receptor β). Ki20227 suppresses osteoclast differentiation and osteolytic bone destruction[1].
- Molecular Weight:
- 480.54
- Purity:
- 99.51
- References:
- [1]Ohno H, et al. A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol Cancer Ther. 2006 Nov;5(11):2634-43.|[2]Boru Hou, et al. Ki20227 influences the morphology of microglia and neurons through inhibition of CSF1R during global ischemia. Int J Clin Exp Pathol. 2016;9(12):12459-12469.
- Research Area:
- Inflammation/Immunology
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Protein Tyrosine Kinase/RTK
