MK-2206 (dihydrochloride)
Product Sizes
5 mg
£ POA
HY-10358-5MG
50 mg
£ POA
HY-10358-50MG
500 mg
£ POA
HY-10358-500MG
100 mg
£ POA
HY-10358-100MG
200 mg
£ POA
HY-10358-200MG
10 mg
£ POA
HY-10358-10MG
25 mg
£ POA
HY-10358-25MG
10mM/1mL
£ POA
HY-10358-10MM
About this Product
- SKU:
- HY-10358
- Additional Names:
- MK-2206 (2HCl)
- CAS Number:
- 1032350-13-2
- Extra Details:
- MK-2206 dihydrochloride (MK-2206 (2HCl)) is an orally active; BBB-penetrated allosteric AKT inhibitor with IC50s of 5 nM; 12 nM; and 65 nM for AKT1; AKT2; and AKT3; respectively. MK-2206 dihydrochloride induces autophagy[1][2].
- Molecular Weight:
- 480.39
- Purity:
- 99.99
- References:
- [1]Zhao YY, et al. Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo. Drug Des Devel Ther. 2014 Oct 10;8:1827-37.|[2]Agarwal E, et al. Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer. BMC Cancer. 2014 Mar 1;14:145.|[3]Li Yan, et al. Abstract #DDT01-1: MK-2206: A potent oral allosteric AKT inhibitor. 2009.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; sealed storage; away from moisture)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Apoptosis;Autophagy;PI3K/Akt/mTOR;Stem Cell/Wnt
