(S)-SNAP5114
Product Sizes
10 mg
£ POA
HY-103504-10MG
100 mg
£ POA
HY-103504-100MG
5 mg
£ POA
HY-103504-5MG
25 mg
£ POA
HY-103504-25MG
50 mg
£ POA
HY-103504-50MG
10mM/1mL
£ POA
HY-103504-10MM
About this Product
- SKU:
- HY-103504
- CAS Number:
- 157604-55-2
- Extra Details:
- (S)-SNAP5114 is a non-covalent murine GABA transporter inhibitor with blood-brain barrier penetration ability; which exhibits significant subtype-selective inhibitory activity against mGAT4 (pIC50=5.71; pKi=4.56); much higher than its effects on mGAT1; mGAT2 and mGAT3. (S)-SNAP5114 elevates extracellular GABA concentrations by blocking the GABA reuptake mechanism; thereby enhancing thalamus-specific GABAergic signaling and exerting potential neuromodulatory effects. (S)-SNAP5114 is widely used in studies related to epilepsy; neuropathic pain; anxiety and depression; and various neurodegenerative diseases[1][2][3].
- Molecular Weight:
- 505.60
- Purity:
- 98.09
- References:
- [1]Borden LA, et al. Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. Receptors Channels. 1994;2(3):207-13.|[2]Borden LA, et al. GABA transporter heterogeneity: pharmacology and cellular localization. Neurochem Int. 1996 Oct;29(4):335-56.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C; 3 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Membrane Transporter/Ion Channel;Neuronal Signaling
