(+)-Niguldipine (hydrochloride)
Product Sizes
5 mg
£ POA
HY-101390-5MG
1 mg
£ POA
HY-101390-1MG
About this Product
- SKU:
- HY-101390
- Additional Names:
- (S)-Niguldipine (hydrochloride)
- CAS Number:
- 113145-69-0
- Extra Details:
- (+)-Niguldipine hydrochloride is an antagonist for calcium channel. (+)-Niguldipine hydrochloride produces vasodilation by blocking calcium channels and reducing the transmembrane influx of calcium ions. (+)-Niguldipine hydrochloride inhibits U-46619 (HY-108566)-induced coronary vasoconstriction in guinea pig Langendorff heart with pID50 of 11.37; binds to calcium channel on guinea pig skeletal muscle membrane with Ki of 9.75; and lowers the blood pressure in spontaneously hypertensive rat with pED30 of 7.1. (+)-Niguldipine hydrochloride ameliorates cardiovascular diseases such as hypertension; angina pectoris and arrhythmias[1].
- Molecular Weight:
- 646.17
- Purity:
- 98.06
- References:
- [1]Eltze M, et al., Stereoselective inhibition of thromboxane-induced coronary vasoconstriction by 1,4-dihydropyridine calcium channel antagonists. Chirality. 1990;2(4):233-40.
- Research Area:
- Cardiovascular Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C (Powder; sealed storage; away from moisture)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Membrane Transporter/Ion Channel;Neuronal Signaling
