(Rac)-BDA-366
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HY-101083A-1EACH
About this Product
- SKU:
- HY-101083A
- Application:
- Antibody Microarray
- CAS Number:
- 142645-19-0
- Extra Details:
- (Rac)-BDA-366 (example 2) is the despinner of BDA-366 (HY-101083). BDA-366 is a potent Bcl-2 antagonist (Ki=3.3 nM); binding Bcl-2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl-2 that abrogates its antiapoptotic function; converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells[1][2].
- Molecular Weight:
- 423.50
- References:
- [1]Spinx Pharmaceuticals Corp. Preparation of bis(hydroxyalkylamino) anthraquinones as protein kinase C inhibitors. World Intellectual Property Organization, WO9207557 A1 1992-05-14|[2]Han B, Park D, Li R, et al. Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy. Cancer Cell. 2015;27(6):852-863.
- Research Area:
- cancer
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
