(E)-4-Hydroxycrotonic acid
Product Sizes
25 mg
£ POA
HY-100982-25MG
100 mg
£ POA
HY-100982-100MG
50 mg
£ POA
HY-100982-50MG
10mM/1mL
£ POA
HY-100982-10MM
About this Product
- SKU:
- HY-100982
- Additional Names:
- trans-4-Hydroxycrotonic acid; trans-γ-Hydroxycrotonic acid; T‐HCA
- CAS Number:
- 24587-49-3
- Extra Details:
- (E)-4-Hydroxycrotonic acid (T-HCA) is a high-affinity ligand for GHB binding sites; with a ki value of 1.1 μM. The introduction of diaryl substituents into (E)-4-Hydroxycrotonic acid significantly enhances its affinity for GHB binding sites; with ki values ranging from 0.023 to 0.075 μM. (E)-4-Hydroxycrotonic acid holds promise for optimizing GHB ligand structures and assisting in the development of effective three-dimensional pharmacophore models[1].
- Molecular Weight:
- 102.09
- Purity:
- 99.83
- References:
- [1]Krall J, et al. Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs. J Med Chem. 2017 Nov 9;60(21):9022-9039.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Membrane Transporter/Ion Channel;Neuronal Signaling
