(R)-(+)-HA-966
Product Sizes
100 mg
£ POA
HY-100822-100MG
10 mg
£ POA
HY-100822-10MG
5 mg
£ POA
HY-100822-5MG
50 mg
£ POA
HY-100822-50MG
25 mg
£ POA
HY-100822-25MG
10mM/1mL
£ POA
HY-100822-10MM
About this Product
- SKU:
- HY-100822
- Additional Names:
- (+)-HA-966
- CAS Number:
- 123931-04-4
- Extra Details:
- (R)-(+)-HA-966 ((+)-HA-966) is a partial agonist/antagonist of glycine site of the N-methyl-D-aspartate (NMDA) receptor complex. (R)-(+)-HA-966 selectively blocks the activation of the mesolimbic dopamine system by amphetamine[1][2]. (R)-(+)-HA-966 can cross the blood-brain barrier and has the potential for neuropathic and acute pain[3].
- Molecular Weight:
- 116.12
- Purity:
- 98.44
- References:
- [1]Hutson PH, et al. R-(+)-HA-966, a glycine/NMDA receptor antagonist, selectively blocks the activation of the mesolimbic dopamine system by amphetamine. Br J Pharmacol. 1991 Aug;103(4):2037-44.|[2]Witkin JM, et al. Discriminative stimulus effects of R-(+)-3-amino-1-hydroxypyrrolid-2-one, [(+)-HA-966], a partial agonist of the strychnine-insensitive modulatory site of the N-methyl-D-aspartate receptor. J Pharmacol Exp Ther. 1995 Dec;275(3):1267-73.|[3]Christensen D, et al. The antinociceptive effect of combined systemic administration of morphine and the glycine/NMDA receptor antagonist, (+)-HA966 in a rat model of peripheral neuropathy. Br J Pharmacol. 1998 Dec;125(8):1641-50.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C; 3 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Membrane Transporter/Ion Channel;Neuronal Signaling
