Acriflavine
Product Sizes
100 mg
£ POA
HY-100575-100MG
50 mg
£ POA
HY-100575-50MG
25 mg
£ POA
HY-100575-25MG
500 mg
£ POA
HY-100575-500MG
1 g
£ POA
HY-100575-1G
10mM/1mL
£ POA
HY-100575-10MM
About this Product
- SKU:
- HY-100575
- Additional Names:
- Acriflavinium (chloride) 3;6-Acridinediamine mix
- Application:
- Antibody Microarray
- CAS Number:
- 8048-52-0
- Extra Details:
- Acriflavine (Acriflavinium chloride) is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine is an antiseptic agent. Acriflavine is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine is used in cancer research; such as breast cancer; brain tumor and chronic myeloid leukemia. Acriflavine is a potent papain-like protease (PLpro) inhibitor; which inhibits SARS-CoV-2[1][2][3][4][5][6].
- Molecular Weight:
- 259.73
- Purity:
- 98.0
- References:
- [1]Chan LM, et al. Interaction of acriflavine with DNA and RNA. J Mol Biol. 1969 Mar 28;40(3):491-5.|[2]Thomas Meinelt, et al. Effects of Calcium Content and Humic Substances on the Toxicity of Acriflavine to Juvenile Zebrafish Danio rerio. Journal of Aquatic Animal Health, 14:1, 35-38.|[3]Voss DM, et al. Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression. Sci Rep. 2017 Jun 27;7(1):4292.|[4]Yin T, et al. HIF-1 Dimerization Inhibitor Acriflavine Enhances Antitumor Activity of Sunitinib in Breast Cancer Model. Oncol Res. 2014;22(3):139-45.|[5]Cheloni G, et al. Targeting chronic myeloid leukemia stem cells with the hypoxia-inducible factor inhibitor acriflavine. Blood. 2017 Aug 3;130(5):655-665.|[6]Napolitano V, et al. Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses. Cell Chem Biol. 2022 May 19;29(5):774-784.e8.
- Research Area:
- Cancer; Infection
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; sealed storage; away from moisture and light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Fluorophores
- Pathway:
- Anti-infection;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Others
