(S)-Crizotinib
Product Sizes
5 mg
£ POA
HY-100549-5MG
50 mg
£ POA
HY-100549-50MG
10 mg
£ POA
HY-100549-10MG
100 mg
£ POA
HY-100549-100MG
25 mg
£ POA
HY-100549-25MG
10mM/1mL
£ POA
HY-100549-10MM
About this Product
- SKU:
- HY-100549
- CAS Number:
- 1374356-45-2
- Extra Details:
- (S)-Crizotinib is a potent and selective MTH1 (mutT homologue) inhibitor with an IC50 of 330 nM. (S)-Crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition; induces an increase in DNA single strand breaks; activates DNA repair in human colon carcinoma cells; and effectively suppresses tumour growth in animal models[1].
- Molecular Weight:
- 450.34
- Purity:
- 99.81
- References:
- [1]Huber KV, et al. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature. 2014 Apr 10;508(7495):222-7.|[2]Dai X, et al. (S)-crizotinib induces apoptosis in human non-small cell lung cancer cells by activating ROS independent of MTH1. J Exp Clin Cancer Res. 2017 Sep 7;36(1):120.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Apoptosis;Cell Cycle/DNA Damage
