PF 477736
Product Sizes
50 mg
£ POA
HY-10032-50MG
5 mg
£ POA
HY-10032-5MG
1 mg
£ POA
HY-10032-1MG
10 mg
£ POA
HY-10032-10MG
100 mg
£ POA
HY-10032-100MG
25 mg
£ POA
HY-10032-25MG
10mM/1mL
£ POA
HY-10032-10MM
About this Product
- SKU:
- HY-10032
- Additional Names:
- PF 00477736
- CAS Number:
- 952021-60-2
- Extra Details:
- PF 477736 (PF 00477736) is a potent; selective and ATP-competitive inhibitor of Chk1; with a Ki of 0.49 nM; it is also a Chk2 inhibitor; with a Ki of 47 nM. PF 477736 shows VEGFR2; Fms; Yes; Aurora-A; FGFR3; Flt3; and Ret (IC50=8 (Ki); 10; 14; 23; 23; 25; and 39 nM; respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo[1][2].
- Molecular Weight:
- 419.48
- Purity:
- 99.04
- References:
- [1]Blasina A, et al. Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1. Mol Cancer Ther. 2008 Aug;7(8):2394-404|[2]Ashwell S, et, al. DNA damage detection and repair pathways--recent advances with inhibitors of checkpoint kinases in cancer therapy. Clin Cancer Res. 2008 Jul 1; 14(13): 4032-7.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Cell Cycle/DNA Damage;Epigenetics;Protein Tyrosine Kinase/RTK
