(Rac)-Nutlin-3
Product Sizes
5 mg
£ POA
HY-10029A-5MG
10 mg
£ POA
HY-10029A-10MG
About this Product
- SKU:
- HY-10029A
- Additional Names:
- (Rac)-Rebemadlin
- Application:
- Antibody Microarray
- CAS Number:
- 890090-75-2
- Extra Details:
- (Rac)-Nutlin-3 (Rebemadlin); an active enantiomer of Nutlin-3; is a potent murine double minute (MDM2) inhibitor (IC50=90 nM). (Rac)-Nutlin-3 inhibits MDM2-p53 interactions and stabilizes the p53 protein; and induces cell autophagy and apoptosis. (Rac)-Nutlin-3 has the potential for the study of TP53 wild-type ovarian carcinomas[1][2].
- Molecular Weight:
- 581.49
- Purity:
- 98.18
- References:
- [1]Crane EK, et al. Nutlin-3a: A Potential Therapeutic Opportunity for TP53 Wild-Type Ovarian Carcinomas. PLoS One. 2015 Aug 6;10(8):e0135101.|[2]Tovar C, et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1888-93.|[3]M Ulrich, et al. Murine tumor models for the in vivo evaluation of natural compounds and their derivatives as new cancer therapeutics. München. 2016.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Apoptosis;Autophagy;Metabolic Enzyme/Protease
