2-Aminoethyl-mono-amide-DOTA-tris(tBu ester)
Product Sizes
1 g
HY-100138-1G
100 mg
HY-100138-100MG
25 mg
HY-100138-25MG
10 mg
HY-100138-10MG
50 mg
HY-100138-50MG
250 mg
HY-100138-250MG
About this Product
- SKU:
- HY-100138
- Application:
- Antibody Microarray
- CAS Number:
- 173308-19-5
- Extra Details:
- 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) is a metal chelator precursor containing a DOTA macrocyclic structure. DOTA can form highly stable complexes with metal ions (such as 68Ga; 177Lu) through four nitrogen atoms and four carboxylic acid groups to mediate targeted delivery of radionuclides. The tert-butyl ester group (tBu ester) of 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) also protects the carboxylic acid group during synthesis; and forms a free carboxyl group after deprotection reaction for coupling with targeting molecules (such as antibodies; peptides). 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) may be combined with tumor pre-targeting systems through bioorthogonal reactions (such as reverse electron demand Diels-Alder reaction) to study radioactive imaging or therapy of tumor tissues; and is mainly used in tumor pre-targeting research in the field of nuclear medicine[1][2].
- Molecular Weight:
- 614.82
- Purity:
- 98.0
- References:
- [1]Läppchen T, et al. DOTA-tetrazine probes with modified linkers for tumor pretargeting. Nucl Med Biol. 2017 Dec;55:19-26.|[2]Oleszko-Torbus, et al. Structural Design of Polymers Conjugated with Bifunctional Chelating Agents. Polymer Reviews (2024): 1-56.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
- Pathway:
- Antibody-drug Conjugate/ADC Related
