Flavopiridol
Product Sizes
10 mg
£ POA
HY-10005-10MG
5 mg
£ POA
HY-10005-5MG
50 mg
£ POA
HY-10005-50MG
100 mg
£ POA
HY-10005-100MG
1 g
£ POA
HY-10005-1G
500 mg
£ POA
HY-10005-500MG
25 mg
£ POA
HY-10005-25MG
10mM/1mL
£ POA
HY-10005-10MM
About this Product
- SKU:
- HY-10005
- Additional Names:
- HMR-1275; Alvocidib; L86-8275
- CAS Number:
- 146426-40-6
- Extra Details:
- Flavopiridol (Alvocidib) is a broad spectrum and competitive inhibitor of CDKs; inhibiting CDK1; CDK2; CDK4 with IC50s of 30; 170; 100 nM; respectively.
- Molecular Weight:
- 401.84
- Purity:
- 99.72
- References:
- [1]Mahoney E, et al. ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.Blood. 2012 Aug 9;120(6):1262-1273.|[2]Keskin H, et al. Complex effects of flavopiridol on the expression of primary response genes. Cell Div. 2012 Mar 29;7:11.|[3]Kim KS, et al.Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects. J Med Chem. 2000 Nov 2;43(22):4126-34.|[4]Jianliang Xu, et al. Inhibition of cyclin E1 sensitizes hepatocellular carcinoma cells to regorafenib by mcl-1 suppression. Cell Commun Signal. 2019 Jul 26;17(1):85.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; stored under nitrogen)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Anti-infection;Apoptosis;Autophagy;Cell Cycle/DNA Damage
