Human PSPN / Persephin Protein (Recombinant)
Product Sizes
20 ug
£ POA
LS-G442-20UG
5 ug
£ POA
LS-G442-5UG
About this Product
- SKU:
- LS-G442
- Additional Names:
- PSPN, PSP, Persephin
- Buffer:
- Sterile filtered, lyophilized from 0.3X PBS, pH 7.2
- Extra Details:
- Persephin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFR alpha (alpha1-alpha4) receptors. The GFRalpha4 was first identified in chicken and was later shown to be the preferential binding subunit for Persephin. Persephin promotes the survival of ventral midbrain dompaminergic neurons and motor neurons after sciatic nerve oxotomy, and like GNDF, promotes ureteric bud branching. However, in contrast to GDNF and Neurturin, Persephin does not support survival of peripheral neurons. Recombinant human Persephin is a disulfide-linked homodimer, composed of two 10.4 kDa polypeptide chains (194 total amino acid residues). Each chain contains seven conserved cysteine residues, one of which (Cys 63) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration. Manufactured under license from the University of Washington patent US 6,716,600; US 6,692,943; US 6,645,937; US 6,403,335; US 6,232,449; US 6,222,022.
- Molecular Weight:
- 10.4 kDa
- Physical State:
- Lyophilized
- Purity:
- >98%
- Shipping Conditions:
- Ambient
- Storage Conditions:
- RT lyophilized. Avoid freeze/thaw cycles., 2-8[o]C lyophilized. Avoid freeze/thaw cycles., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- LifeSpan Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:442
