Mouse PDGF-AA Protein (Recombinant)
Product Sizes
1 unit
£ POA
LS-G27296-1UNIT
10 units
£ POA
LS-G27296-10UNITS
50 units
£ POA
LS-G27296-50UNITS
About this Product
- SKU:
- LS-G27296
- Additional Names:
- PDGFA, PDGF-A, PDGF A-chain, PDGF subunit A, PDGF-1, PDGF1
- Buffer:
- Lyophilized from PBS
- Extra Details:
- Platelet-Derived Growth Factor-AA (PDGF-AA) is one of five dimers (PDGF-AA, AB, BB, CC, and DD) formed by 4 different PDGF subunits. In chemical terms, platelet-derived growth factor is a dimeric glycoprotein composed of two A (-AA) or two B (-BB) chains or a combination of the two (-AB). The dimeric isoforms PDGF-AA, AB and BB are differentially expressed in various cell types, and their effects are mediated through two distinct receptors termed a and Beta. Differences exist in isoform binding to each receptor. Ingeneral, PDGF isoforms are potent mitogens for connective tissue cells including dermal fibroblasts, glial cells, arterial smooth muscle cells and some epithelial andendothelial cells. In addition to its activity as a mitogen, PDGF is chemotactic for fibroblasts, smooth muscle cells, neutrophils and mononuclear cells. PDGF-AA plays a significant role in blood vessel formation (angiogenesis).Recombinant Mouse Platelet-Derived Growth Factor-AA(PDGF-AA) produced in E.coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 125 amino acids each. A fully biologically active molecule, rmPDGF-AA has a molecular mass of 28.7 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
- Molecular Weight:
- 28.7 kDa (SDS-PAGE)
- Physical State:
- Lyophilized
- Purity:
- >95%
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C reconstituted., -20[o]C reconstituted. Avoid freeze/thaw cycles., -70[o]C Avoid freeze/thaw cycles.
- Supplier:
- LifeSpan Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:27296
