Mouse NTF4 / Neurotrophin 4 Protein (Recombinant)
Product Sizes
1 unit
£ POA
LS-G27239-1UNIT
10 units
£ POA
LS-G27239-10UNITS
50 units
£ POA
LS-G27239-50UNITS
About this Product
- SKU:
- LS-G27239
- Additional Names:
- NTF4, GLC1O, GLC10, Neurotrophic factor 5, NT-4, Neurotrophic factor 4, Neurotrophin-4, Neurotrophin-4 precursor, NT-5, NT4, NT5, NTF5, Neurotrophin 4, Neurotrophin-5, Neutrophic factor 4, NT-4/5
- Buffer:
- Lyophilized from 50 mM acetic acid.
- Extra Details:
- Neurotrophin-4 (NT-4) is a small secreted cytokine, and belongs to the Neurotrophin (NT) family, which also includes Brain Derived Neurotropic Factor (BDNF), Nerve Growth Factor (NGF), and NT-3. NT family members are all derived from similar sized protein precursors, composed of N-terminal propeptides and C-terminal mature domains, which are separated by posttranslational proteolytic cleavage. NT-4 (along with NT-3) is foundin the brains of mammals. In vivo, NT-4 binds to the common receptor, p75NTR, and a tyrosine kinase receptor, TrkB. The heterotrimeric complex activates the NF-kappaB transcription factor. NT-4 is essential for the differentiation and wiring regulation of the central and peripheral nervous systems during development, and is related to important diseases including Alzheimer's.Recombinant mouse Neurotrophin-4 (rmNT-4) produced in E. coli is a noncovalently linked homodimer containing two non-glycosylated polypeptide chainsof 131 amino acids. A fully biologically active molecule, rmNT-4 has a molecular mass of 14.0kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
- Molecular Weight:
- 14.0 kDa (SDS-PAGE)
- Physical State:
- Lyophilized
- Purity:
- >95%
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., -70[o]C Avoid freeze/thaw cycles., 2-8[o]C reconstituted.
- Supplier:
- LifeSpan Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:27239
