Human IL18BP Protein (Recombinant)
Product Sizes
1 unit
£ POA
LS-G27228-1UNIT
10 units
£ POA
LS-G27228-10UNITS
50 units
£ POA
LS-G27228-50UNITS
About this Product
- SKU:
- LS-G27228
- Additional Names:
- IL18BP, IL18BPa, Interleukin-18-binding protein, Interleukin 18 binding protein, Tadekinig-alfa, IL-18BP
- Buffer:
- Lyophilized from PBS
- Extra Details:
- Interleukin-18 binding protein, also known as IL-18BP and tadekinig-alfa, is a secreted glycoprotein that contains an Ig-like C2-type domain. It is expressed in heart, lung, placenta and spleen. IL-18BP functions as an inhibitor of the proinflammatory cytokine IL-18. It binds to IL-18, prevents the binding of IL-18 to its receptor, and thus blocks IL-18-induced IFN-gamma production. The complete Ig domain has been shown to mediate the binding and neutralizing properties. IFN-gamma is able to upregulate the expression of IL-18BP, indicating that IL-18 activity is regulated by a feedback mechanism through IL-18BP.
- Molecular Weight:
- 42-44 kDa (SDS-PAGE)
- Physical State:
- Lyophilized
- Purity:
- >95%
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C reconstituted., -20[o]C reconstituted. Avoid freeze/thaw cycles., -70[o]C Avoid freeze/thaw cycles.
- Supplier:
- LifeSpan Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:27228
