Human FGF21 Protein (Recombinant)
Product Sizes
1 unit
£ POA
LS-G27217-1UNIT
10 units
£ POA
LS-G27217-10UNITS
50 units
£ POA
LS-G27217-50UNITS
About this Product
- SKU:
- LS-G27217
- Additional Names:
- FGF21, Fibroblast growth factor 21, FGF-21
- Buffer:
- Lyophilized from PBS
- Extra Details:
- Fibroblast Growth Factor-21 (FGF-21) is a metabolic cytokine belonging to the heparin-binding FGF family. Along with FGF-19/15 and FGF-23, FGF-21 is categorized as a member of the atypical FGF subfamily, as it must be complexed to the Klotho co-receptor in order to bind to the FGF receptors and activate the downstream signaling pathway. In vivo FGF-21 is expressed in liver, pancreas, adipose tissue, and skeletal muscle, and it plays a central role in the energy metabolism. The expression of FGF-21 is stimulated by free fatty acids and insulin resistant states and is correlated with whole-body insulin resistance. FGF-21 activates glucose uptake in adipocytes and increases insulin sensitivity, implicating it as a novel target with potential anti-diabetic properties.Recombinant human Fibroblast Growth Factor-21 (rhFGF-21) produced in E. coli is a single non-glycosylated polypeptide chain containing 182 amino acids. A fully biologically active molecule, rhFGF-21 has a molecular mass of 19.5 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
- Molecular Weight:
- 19.5 kDa (SDS-PAGE)
- Physical State:
- Lyophilized
- Purity:
- >95%
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., -70[o]C Avoid freeze/thaw cycles., 2-8[o]C reconstituted.
- Supplier:
- LifeSpan Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:27217
