PD-1 / Fc Chimera Protein (Recombinant)
Product Sizes
1 unit
£ POA
LS-G27024-1UNIT
50 units
£ POA
LS-G27024-50UNITS
About this Product
- SKU:
- LS-G27024
- Buffer:
- Lyophilized from Sterile Solution PBS
- Extra Details:
- Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279) or PDCD1, is a protein that in humans is encoded by the PDCD1 gene. PD-1 is a cell surface receptor that belongs to the immunoglobulin superfamily and is expressed on T cells and pro-B cells.PD-1 binds two ligands, PD-L1 and PD-L2. PD-1 and its ligands play an important role in down regulating the immune system by preventing the activation of T-cells, which in turn reduces autoimmunity and promotes self-tolerance. The inhibitory effect of PD-1 is accomplished through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (suppressor T cells) Recombinant Human PD-1 produced in CHO cells with C-terminal Fc tag, is a polypeptide chain containing 376 amino acids. A fully biologically active molecule, rhPD-1 has a molecular mass of 60-65 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
- Molecular Weight:
- 60-65 kDa (SDS-PAGE)
- Physical State:
- Lyophilized
- Purity:
- >98%
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -70[o]C Avoid freeze/thaw cycles.
- Supplier:
- LifeSpan Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:27024
