Coronavirus SARS-CoV-2 Orf1ab Polyprotein (Recombinant) (Glu1564-Lys1878)
Product Sizes
10 ug
£ POA
LS-G145879-10UG
About this Product
- SKU:
- LS-G145879
- Buffer:
- Sterile solution in 20 mM Tris-HCl, pH 7.5, 10 mM Beta-ME, 20% Glycerol
- Concentration:
- 1.5 mg/ml
- Extra Details:
- Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. PLpro is a cysteine protease located within the non-structural protein 3 (NS3) section of the viral polypeptide. PLPro activity is required to process the viral polyprotein into functional, mature subunits; specifically, PLPro cleaves a site at the amino-terminus of the viral replicase region. In addition to its role in viral protein maturation, PLPro possesses a deubiquitinating and deISGylating activity. In vivo, this protease antagonizes innate immunity by inhibiting IRF3-induced production of type I interferons.
- Molecular Weight:
- 35.8 kDa
- Purity:
- >90%
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- LifeSpan Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:145879
