Human IL36A Protein (Recombinant)
Product Sizes
10 ug
£ POA
LS-G133800-10UG
2 ug
£ POA
LS-G133800-2UG
About this Product
- SKU:
- LS-G133800
- Additional Names:
- IL36A, FIL1, FIL1 epsilon, IL-1F6, IL1(EPSILON), IL1E, IL1F6, Interleukin 1, epsilon, Interleukin 36, alpha, Interleukin-1 epsilon, Interleukin-1 family member 6, FIL1(EPSILON), FIL1E, IL-1 epsilon, IL-1F6 (FIL-1-epsilon), Interleukin-36 alpha
- Buffer:
- Lyophilized
- Extra Details:
- The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36a (IL-1F6), B Beta (IL-1F8), and ? (IL-1F9). IL-36a is highly expressed in psoriatic plaques, as are IL-36B Beta and IL-36?, and is the only IL-1 family member found to be expressed by T-cells, as well as monocytes and B-cells. Primarily found in skin and lymphoid tissues, IL-36a is also found to a lesser extent in tissues of the fetal brain, trachea, stomach, and intestine. IL-36a signals through a combination of the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells, and the widely expressed IL-RAcP (IL-1 receptor accessory protein). IL-36a also functions as an agonist of NF-kappaB and MAPK pathways, and induces the production of proinflammatory cytokines and chemokines, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36a is a 17.2 kDa protein containing 154 amino acid residues.
- Molecular Weight:
- 17.2 kDa
- Physical State:
- Lyophilized
- Purity:
- >98%
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles. Desiccated.
- Supplier:
- LifeSpan Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:133800
