Human Soluble Interleukin 6 Receptor Alpha (sIL6Ra) Protein (Recombinant)
Product Sizes
20 ug
£ POA
LS-G133797-20UG
5 ug
£ POA
LS-G133797-5UG
About this Product
- SKU:
- LS-G133797
- Buffer:
- Lyophilized
- Extra Details:
- IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6Ra and gp130. While the IL-6Ra chain is the binding component specific to IL-6, the gp130 chain only transmits signals of IL-6 when bound to IL-6Ra. The gp130 can also transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6Ra alone. IL-6Ra is expressed in a wide range of cells, including T cells, fibroblasts and macrophages. Soluble IL-6Ra, which consists of only the extracellular domain of the IL-6Ra chain, acts as an agonist of IL-6 activity at low concentrations. PeproTech's CHO cell-derived Recombinant Human sIL-6 Receptor a is a 37.9 kDa glycoprotein corresponding to 339 amino acid residues of the extracellular domain of IL-6Ra. As a result of glycosylation, Recombinant Human sIL-6 Receptor a migrates with an apparent molecular mass of approximately 57-70 kDa by SDS-PAGE gel, under reducing conditions.
- Molecular Weight:
- 37.9 kDa or 57-70 kDa
- Physical State:
- Lyophilized
- Purity:
- >95%
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles. Desiccated.
- Supplier:
- LifeSpan Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:133797
