Human Soluble Interleukin 2 Receptor Alpha (sIL2Ra) Protein (Recombinant)
Product Sizes
25 ug
£ POA
LS-G133795-25UG
5 ug
£ POA
LS-G133795-5UG
About this Product
- SKU:
- LS-G133795
- Buffer:
- Lyophilized
- Extra Details:
- The IL-2 receptor system consists of three non-covalently linked subunits termed IL-2Ra, IL-2RB Beta, and IL-2R?. The IL-2Ra is a type I transmembrane protein consisting of a 219 amino acid extracellular domain, a 19 amino acid transmembrane domain and a 13 amino acid intracellular domain, which is not involved in the transduction of IL-2 signals. Proteolytic processing of IL-2Ra releases the entire extracellular domain of IL-2Ra, thereby generating a 219 amino acid soluble protein called soluble IL-2Ra (sIL-2Ra). The homodimeric form binds IL-2 (KD=10mM) and facilitates IL-2 signaling. The secreted sIL-2Ra is expressed on leukemia cells, lymphoma cells, and newly activated T and B cells, as well as on approximately 10% of NK cells. Recombinant Human sIL-2 Receptor a is a 24.8 kDa protein containing 219 amino acid residues consisting of only the extracellular domain of IL-2Ra. As a result of glycosylation, Recombinant Human sIL-2 Receptor a migrates with an apparent molecular mass of approximately 40-50 kDa by SDS-PAGE gel, under reducing and non-reducing conditions.
- Molecular Weight:
- 24.8 kDa or 40-50 kDa
- Physical State:
- Lyophilized
- Purity:
- >98%
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles. Desiccated.
- Supplier:
- LifeSpan Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:133795
