UBE2A, His6
Product Sizes
3 nmol
£523.00
UB-226H-0030-3NMOL
About this Product
- SKU:
- UB-226H-0030
- Application:
- Cell-based/Functional Assay
- Extra Details:
- UBE2A is an E2 conjugation enzyme that is involved in the ubiquitylation of target substrates, along with E1 and E3 enzymes. UBE2A is a substrate for cyclin-dependent kinase 2 with phosphorylation of Ser120, dramatically increasing ubiquitin conjugating activity. During the cell cycle, peak phosphorylation of UBE2A coincides with peak ubiquitylation of histone H2B. Ubiquitylated H2B stimulates methylation of lysine 4 of histone H3. UBE2A and B are also involved in DNA lesion repair via recruitment of alternative polymerases to DNA. UBE2A has been implicated in regulating the ubiquitylation of aggregating proteins along with UBE2K and UBE2D2.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- LifeSensors
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
