NMS-873
Product Sizes
5 mg
£396.00
SI-9752-0005-5MG
About this Product
- SKU:
- SI-9752-0005
- Application:
- Cell-based/Functional Assay
- CAS Number:
- 1418013-75-8
- Extra Details:
- p97 (aka VCP, Cdc48) is intimately involved in the ERAD process through the retrotranslocation of misfolded proteins targeted for degradation by the proteasome. It is a homohexamer of AAA+ ATPase subunits and ATP hydrolysis is required for protein extraction from the ER. NMS-873 is an allosteric inhibitor of ATPase activity, binding to the D1 and D2 domains of adjacent subunits (Magnaghi, D'Alessio et al. 2013). NMS-873 is reported to have an IC50 for p97 of 20-30nM.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- LifeSensors
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
