K63-Linked Tetra-Ubiquitin, TAMRA-labeled
Product Sizes
K63-Linked Tetra-Ubiquitin, TAMRA-labeled
£907.00
SI-6304-T025
About this Product
- SKU:
- SI-6304-T025
- Additional Names:
- HMG20;polyubiquitin-C
- Application:
- Cell-based/Functional Assay
- Conjugate:
- TRITC
- Extra Details:
- Poly-ubiquitination of target proteins through K63 has recently become the focus of intense study. The topology of this linkage type is quite different from polyubiquitin linked through lysine 48. Modification of proteins by K63-linked poly-ubiquitination has been implicated in, among other cellular processes, the regulation of the DNA damage response, endosomal sorting, autophagy of misfolded/aggregated proteins, neurodegeneration, and signal transduction. These tetra-ubiquitin chains are generated from the enzymatic linkage of wild-type ubiquitin through lysine 63. The most distal ubiquitin contains an arginine substitution for a lysine at position 63, limiting chain length. The TAMRA moiety is attached to a single, non-lysine site in the proximal ubiquitin.
- Gene Details:
- UBC
- Protein Details:
- P0CG48
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C
- Size:
- 25 ug
- Supplier:
- LifeSensors
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
- Manufacturer's Data Sheet:https://lifesensors.com/product/si6304t-k63-linked-tetra-ubiquitin-tamra-labeled/