K63-Linked Tri-Ubiquitin
Product Sizes
100 ug
£582.00
SI-6303-0100-100UG
About this Product
- SKU:
- SI-6303-0100
- Additional Names:
- HMG20;polyubiquitin-C
- Application:
- Cell-based/Functional Assay
- Extra Details:
- Poly-ubiquitination of target proteins through K63 has recently become the focus of intense study. The topology of this linkage type is quite different from polyubiquitin linked through lysine 48. Modification of proteins by K63-linked poly-ubiquitination has been implicated in, among other cellular processes, the regulation of the DNA damage response, endosomal sorting, autophagy of misfolded/aggregated proteins, neurodegeneration, and signal transduction. These triubiquitin chains are generated from the enzymatic linkage of wild-type ubiquitin through lysine 63. The most distal ubiquitin contains an arginine substitution for the lysine at position 63, limiting chain length.
- Gene Details:
- UBC
- Protein Details:
- P0CG48
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- LifeSensors
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:https://lifesensors.com/product/si6303-k63-linked-tri-ubiquitin/