K48-Linked Tetra-Ubiquitin
Product Sizes
25 ug
£368.00
SI-4804-0025-25UG
About this Product
- SKU:
- SI-4804-0025
- Additional Names:
- HMG20;polyubiquitin-C
- Application:
- Cell-based/Functional Assay
- Extra Details:
- Poly-ubiquitylation of target proteins through linkage at K48 is the most thoroughly studied of the various ubiquitin chain linkages. It is now clear that many, if not all, poly-Ub chain topologies are likely to play distinct and important roles in regulating cellular processes. Nevertheless, K48 linkages remain a critical pathway for cells to maintain protein homeostasis and remain intriguing for the study of DUBs that play a role in regulating degradation, as well as the proteasome itself. These tetra-ubiquitin chains generated from the enzymatic linkage (E2-25K) of wild-type ubiquitin through lysine 48. The most distal ubiquitin contains an arginine substitution for the lysine at position 48, limiting chain length.
- Gene Details:
- UBC
- Protein Details:
- P0CG48
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- LifeSensors
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:https://lifesensors.com/product/si4804-k48-linked-tetra-ubiquitin/